Thalassemia is an inherited (i.e., passed from parents to children through genes) blood disorder caused when the body doesn’t make enough of a protein called hemoglobin, an important part of red blood cells.
Types of blood cells in human
Difference between Normal Vs Thalassemia
Burden of disease in India
β-thalassemia is the commonest single-gene disorder in the Indian population.
10% of the total world thalassemics are born in India every year
The incidence varying from 1 to 17%
The prevalence of pathological hemoglobinopathies in India is 1.2/1,000 live births
With approximately 27 million births per year this would suggest the annual birth of 32,400 babies with a serious hemoglobin disorder.
Effects of Thalassemia
Proposed model
BMT
Chelation
Transfusion
Treatment
Curative – BMT (Bone Marrow Transplant)
Supportive
Blood transfusion [proper]
Chelation
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